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2019 Paul Kleijnen

Towards MRI-Guided rectal cancer boost radiotherapy


This thesis focuses on filling the knowledge gaps for an effective introduction of MRI-guided boost treatments for rectal cancer. Also existing knowledge on CTV motion is redefined, using the benefits of MRI’s superior soft tissue contrast, thereby improving the standard treatment. In this thesis the preparatory steps for introduction of MRI-guided radiotherapy in rectal cancer are discussed. These steps include evaluating the limitations of the current standard of care CT-guided treatment and assessing where MRI-guided radiotherapy can reduce these limitations by using the benefits of the superior soft tissue contrast of the MRI.


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